Seattle’s first lady of comedy Peggy Platt will headline the DoVE Project’s second annual comedy night “Laughter is the Best Medicine” at 6 p.m. Saturday at the Open Space for Arts & Community.

Opening for the likes of Jay Leno, Jerry Seinfeld, Kathy Griffin and Cyndi Lauper, Platt is the only woman to date to have won the prestigious Seattle International Comedy Competition. Three other Seattle comedians, plus Vashon’s Tami Brockway Joyce and Jennifer Sutherland, Duo Finelli and Chip and Margie will be joining Platt.

Kathi Jenkins, chair of DoVE’s board of directors, said proceeds from Saturday’s event will go toward advocacy efforts for domestic violence survivors and community outreach and will include training new advocates.

While the nonprofit currently has 17 volunteers, Jenkins said the advocacy job is very stressful, so volunteers typically cover about one phone shift per week. Yet the need is great, for as with the national average, one in three people on Vashon is affected by domestic volence.

Tickets are $35 and available at www. brownpapertickets.com, at Vashon Bookshop and at the door. There will be a no-host bar, and light appetizers will be provided by Herban Feast.

The event is for adults only.